Here’s a few [lesser] known Windows shortcuts: (feel free to share more in the comments!)
WinKey + E : Windows Explorer
WinKey + R : Run
WinKey + F : Find (Windows Search)
WinKey + L : Lock computer
WinKey + Pause/Break : Computer properties
CTRL + LEFT SHIFT + ESC : Task Manager
CTRL + ALT + END : Shows Shutdown menu *on remote machine*
Complete list of Microsoft Shortcuts here: http://support.microsoft.com/kb/126449